The war had been going on for nearly a year and the Sirian Empire had a huge advantage in personnel and equipment. Earth needed an edge. Which was where James Mowry came in. If a small insect buzzing around in a car could so distract the driver as to cause that vehicle to crash, think what havoc one properly trained operative could wreak on an unuspecting enemy. Intensively trained, his appearance surgically altered, James Mowry is landed on Jaimec, the ninety-fourth planet of the Sirian Empire. His mission is simple: sap morale, cause mayhem, tie up resources, wage a one-man war on a planet of eighty million. In short, be a wasp. First published in 1957, WASP is generally regarded as Eric Frank Russell's best novel, a witty and exciting account of a covert war in the heart of enemy territory.
A nine-year-old boy living in a New England mill town dreams of reuniting his separated parents after his mother catches his father having an affair and throws him out and the father makes nightly returns to plot a reunification with his son. Reader's Guide included. Reprint.
True stories for aviation history buffs. Topics include WASP (Women Airforce Service Pilots); National WWII WASP Museum in Sweetwater; RAF (Royal Air Force) in Texas; Avenger Field in Sweetwater, Texas; P-47 Fighter Pilot Otto Carter and "The Sweetwater Swatter"; Pioneer Museum in Sweetwater; C-47 Crash and Memorial in Nolan Co., Texas; Charles Lindbergh in the Pacific in World War II; Military Gliders in World War II, including story of Combat Glider Pilot George Theis in Operation Varsity; South Plains Army Air Field; Silent Wings Museum in Lubbock, Texas; 348th Fighter Group; 340th Fighter Squadron (Minutemen); 460th Fighter Squadron (Black Rams); B-24 flight instructor A. N. Densmore; WASP flight instructor, Rigdon Edwards; Neel Kearby; Bill Dunham; and others. Also includes many historic photos and original artwork by Scott Morgan, Michael Vincent, and Otto Carter, III.
Tumor metastasis is usually associated with a poor prognosis for cancer patients. Notably, this pathological process is correlated with elevated expression and phosphorylation of f & barbelow;ocal a & barbelow;dhesion k & barbelow;inase (FAK), a non-receptor tyrosine kinase whose activity is regulated by the adhesive state of a cell. In order to metastasize, neoplastic cells must invade into the surrounding tissues and into the vascular systems. Tumor cell invasion is a complex process that generally involves the degradation of the surrounding e & barbelow;xtrac & barbelow;ellular m & barbelow;atrices (ECMs) followed by directional cell movement. To explore the molecular mechanism underlying the potential function of FAK in cell invasion, we generated transformed cell lines by stable expression of v-Src in FAK deficient (FAK-/- ) and wild type (FAK+/+) cells. Interestingly, we found that FAK played a central role in invasion through inhibiting endocytosis of a key cell-surface proteinase, MT1-MMP. We identified an interaction between FAK and endophilin A2 and showed that this interaction allowed phosphorylation of endophilin A2 at Tyr315 by a FAK/Src complex. This phosphorylation event disrupts the endophilin/dynamin complex that plays an essential role in endocytosis, thus attenuating endocytosis of MT1-MMP. In this way, FAK upregulates surface expression of MTI-MMP and consequent ability of cells to degrade the ECMs. In addition to regulation of ECM dissolution, FAK has also been implicated in controlling cell migration. We found that FAK associated and phosphorylated N-WASP at Tyr256. Our results also indicated that N-WASP localized in both the cytoplasm and the nucleus. Nuclear translocation of N-WASP is dependent on its being in the open conformation and could serve as a negative feedback loop to tune down its cytoplasmic function. Phosphorylation of Tyr256 of N-WASP could sustain N-WASP activation in the cytoplasm by inhibiting its nuclear translocation, thus facilitating cell migration. The nuclear localization of N-WASP inspired us to further analyze its potential functions in the nucleus. We found that nuclear N-WASP is within a large protein complex containing PSF/NonO, nuclear actin, and RNA polymerase II. Moreover, we presented evidence to elucidate a fundamental role of N-WASP in RNA polymerase II-dependent transcription.
For fans of WHAT IF? and NEW SCIENTIST comes this brilliantly funny and informative look at the stranger side of evolution. Featuring: The Zombie ants mind-controlled by a fungus Beautiful salamanders that can regenerate any part of their bodies, including their brains The mantis shrimp, which fires its club-like appendage so fast that the surrounding water becomes as hot as the surface of the sun The Antechinus, whose runaway testosterone levels cause them to have so much sex during their three-week mating season that they bleed internally, go blind, and drop dead... Featuring quirky illustrations and the signature blend of science smarts and humour that make Matt Simon's Wired column so entertaining, this is an ideal stocking-filler for every popular science aficionado...
While describing the archetypal White Anglo-Saxon Protestant--both male and female--the authors analyze the WASP attitude and the set of values that it has established for all Americans
Fraser offers a groundbreaking contribution to the project of synthesizing Anglo-American constitutional and legal history with the evolutionary biology of ethnicity and a Christian ethno-theology. "The WASP Question" is valuable for focusing attention on the plight of Anglo-Saxon societies assailed by runaway materialism and imposed diversity.
This volume features poems about Japan, America post 9/11, Britain post Dutch elm disease and other environmental disasters, as well as poems of travel, humour, satire and love.